Item Type | Name |
Concept
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Islets of Langerhans
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Concept
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Islets of Langerhans Transplantation
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Academic Article
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Distinct gene expression pathways in islets from individuals with short- and long-duration type 1 diabetes.
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Academic Article
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Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus.
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Academic Article
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Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.
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Academic Article
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Differential expression of cell cycle proteins during ageing of pancreatic islet cells.
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Academic Article
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IFN-a induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells.
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Academic Article
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Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.
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Academic Article
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Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes.
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Academic Article
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The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.
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Academic Article
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Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.
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Academic Article
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A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo.
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Academic Article
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The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice.
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Academic Article
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A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis.
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Academic Article
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1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor.
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Academic Article
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Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding.
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Academic Article
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In situ type I oligomeric collagen macroencapsulation promotes islet longevity and function in vitro and in vivo.
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Academic Article
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AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.
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Academic Article
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Mouse and human islets survive and function after coating by biosilicification.
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Academic Article
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Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.
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Academic Article
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Proendocrine genes coordinate the pancreatic islet differentiation program in vitro.
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Academic Article
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Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes.
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Academic Article
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Expression and function of Set7/9 in pancreatic islets.
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Academic Article
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SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet ß Cell.
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Academic Article
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The C-terminal domain of the beta cell homeodomain factor Nkx6.1 enhances sequence-selective DNA binding at the insulin promoter.
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Academic Article
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Development of insulin-producing cells from primitive biologic precursors.
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Academic Article
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Deletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes development.
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Academic Article
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Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells.
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Academic Article
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Research resource: nuclear hormone receptor expression in the endocrine pancreas.
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Academic Article
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Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.
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Academic Article
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12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.
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Academic Article
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12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets.
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Academic Article
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Transcription factors direct the development and function of pancreatic beta cells.
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Academic Article
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Regulation of the pancreatic pro-endocrine gene neurogenin3.
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Academic Article
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Combined Analysis of GAD65, miR-375, and Unmethylated Insulin DNA Following Islet Transplantation in Patients With T1D.
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Academic Article
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Mouse islet of Langerhans isolation using a combination of purified collagenase and neutral protease.
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Academic Article
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Comparative quantitative proteomic analysis of disease stratified laser captured microdissected human islets identifies proteins and pathways potentially related to type 1 diabetes.
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Academic Article
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Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet ß Cell Death.
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Academic Article
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Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1.
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Academic Article
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From immunobiology to ß-cell biology: the changing perspective on type 1 diabetes.
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Academic Article
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Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure.
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Academic Article
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Maintenance of Pdx1 mRNA translation in islet ß-cells during the unfolded protein response.
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Academic Article
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The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.
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Academic Article
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Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains.
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Academic Article
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Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.
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Academic Article
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Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells.
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Academic Article
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The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.
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Academic Article
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Biomarkers of islet beta cell stress and death in type 1 diabetes.
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Academic Article
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Profiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 Diabetes.
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Academic Article
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Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention.
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Academic Article
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Oligomeric collagen as an encapsulation material for islet/ß-cell replacement: effect of islet source, dose, implant site, and administration format.
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Academic Article
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Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes.
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Academic Article
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The demise of islet allotransplantation in the United States: A call for an urgent regulatory update.
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